- Nasacort and Flonase are both corticosteroid nasal sprays that help alleviate symptoms of allergic rhinitis, but they differ in their formulations, onset of action, and side effects.
- Nasacort (triamcinolone) relieves nasal congestion, sneezing, and itchy eyes, with relief starting in 12 hours and full benefits in 2 to 3 days. Flonase (fluticasone propionate) offers similar relief, with quicker initial improvement (2 to 4 hours) and full benefits in 2 to 3 days.
- An alternative to Nasacort and Flonase is Allermi — a combination nasal spray that targets multiple allergy symptoms and provides quick relief within 10 to 15 minutes.
Nasal sprays are a go-to solution for many people looking to relieve the frustrating symptoms of allergic rhinitis, including sneezing, a runny nose, and nasal congestion. These sprays deliver targeted relief directly to inflamed nasal passages.
Two popular options, Nasacort and Flonase, contain corticosteroids, which are known for their anti-inflammatory properties, yet they differ in their formulations, usage, and potential side effects.
In this article, we'll not only compare these two medications but also explore an alternative option that could provide similar or even better results.
Related: How Long Does It Take for Allergy Medicine to Work?
What is Nasacort?
Nasacort is a corticosteroid nasal spray used to treat allergy symptoms such as nasal congestion, sneezing, runny nose, and itchy or watery eyes. Its active ingredient triamcinolone acetonide works by inhibiting the production and release of various inflammatory mediators such as histamine, prostaglandins, and leukotrienes, which are responsible for the symptoms of allergies [*].
Nasacort is available over the counter and is typically used once daily. It is suitable for adults and children aged 2 years and older, though dosage may vary depending on age.
What is Flonase?
Flonase nasal spray contains fluticasone propionate, a corticosteroid known for its anti-inflammatory properties. This mechanism effectively relieves allergy symptoms like nasal congestion, sneezing, a runny nose, and itchy or watery eyes.
Fluticasone propionate works by addressing the root cause of allergy symptoms. It calms the immune response and alleviates nasal swelling. Additionally, it blocks the release of key chemicals in the nasal passage involved in the allergic cascade, such as histamines and leukotrienes [*].
Note: Flonase Sensimist and Flonase Allergy Relief are both 24-hour corticosteroid nasal sprays with fluticasone propionate, which provides relief from allergy symptoms like nasal congestion and itchy, watery eyes.
- Flonase Sensimist features MistPro Technology for a fine, gentle mist, an ergonomic side-press bottle, and a scent-free, no-drip formula — it’s ideal for sensitive users.
- Flonase Allergy Relief offers the same symptom relief as a traditional press-down application — it’s a straightforward and effective option for managing allergies.
For younger users, Children’s Flonase Sensimist is a kid-friendly option designed for children aged 2 years and older. Its gentle mist and single-dose daily application make it a practical and effective choice for children.
Related: Afrin vs. Flonase: Differences and Alternatives
Nasacort vs. Flonase
Both Nasacort and Flonase offer effective relief for allergy symptoms, but how do you decide which one is the best fit for your needs? Here is a comparison of their onset of action, duration, and side effects.
| Nasacort | Flonase | |
| Drug Class | Corticosteroids | Corticosteroids |
| Generic Name | Triamcinolone | Fluticasone Propionate |
| Indications | Alleviates symptoms caused by seasonal and perennial allergic rhinitis, such as nasal congestion, sneezing, runny nose, itchy or watery eyes, and nasal itching, and other symptoms. | Highly effective in managing allergy symptoms such as nasal congestion, sneezing, runny nose, itchy nose, and itchy, watery eyes. It provides relief from symptoms caused by both indoor allergens, like dust mites, pet dander, and mold, and outdoor allergens. |
| Side Effects | Common side effects include nasal irritation, such as dryness, discomfort, or a burning or stinging sensation in the nasal passages, as well as sneezing, headaches, and sore throat. Some individuals may experience nosebleeds (epistaxis) or crusting inside the nose due to its drying effects on the nasal mucosa. Prolonged use at high doses may increase the risk of infections. | Common side effects of Flonase include nasal irritation, which may manifest as burning, dryness, or discomfort in the nasal passages, as well as occasional nosebleeds. Some users report experiencing headaches, sore throat, coughing, or gastrointestinal symptoms such as nausea or vomiting. Allergic reactions, such as rash, swelling of the face or throat, or difficulty breathing, may occur and should be addressed immediately. |
| Duration/Course | Generally effective for 24 hours after a single dose | Provides 24-hour relief |
| Onset | Typically shows improvement in symptoms as early as 12 hours after the first dose. However, full therapeutic benefits are generally expected within 2 to 3 days of consistent use. There is a possible delayed response (up to 2 weeks) in some patients. | Occurs within 12 hours after the first dose, and some patients may experience relief as early as 2 to 4 hours. While initial relief is noticeable within this timeframe, the maximum benefit usually requires 2 to 3 days of consistent use. |
| Dosage | For adults and children aged 2 years and older: Start with 2 sprays in each nostril once daily. Once symptoms are under control, the dosage may be reduced to 1 spray per nostril daily for maintenance. Always follow the specific dosage instructions provided on the product label or by your healthcare provider. | For adults and children aged 12 years and older, the recommended starting dose is 2 sprays in each nostril once daily. Once symptoms improve, the dose can be reduced to 1 spray in each nostril daily for maintenance. For children aged 4 to 11 years, the typical dosage is 1 spray in each nostril once daily, under adult supervision. Always follow the dosage instructions on the product label and consult a healthcare provider before starting or adjusting the medication. |
| Drug Interaction | Certain medications, like ketoconazole, erythromycin, clarithromycin, and albuterol, can increase Nasacort levels or side effects. Aspirin and ibuprofen may irritate the stomach, raising the risk of bleeding, while montelukast and prednisone can amplify effects or side effects. Always consult a healthcare provider about potential interactions. | May interact with medications like ketoconazole, erythromycin, clarithromycin, and ritonavir, which can increase Flonase levels and heighten side effects. Combining Flonase with desmopressin may increase the risk of low sodium or water retention. Additionally, using Flonase with other corticosteroids could increase the risk of corticosteroid-related side effects. |
| Warnings/Precautions | Do not use Nasacort if you are allergic to triamcinolone or any of its ingredients. Nasacort is not recommended for children under 2 years of age. Moreover, patients who have had recent nasal surgery, trauma, or ulcers should avoid using Nasacort until healing has occurred, as corticosteroids can inhibit wound healing. | Do not use Flonase if you have experienced recent nasal ulcers, nasal surgery, or nasal trauma until healing has occurred. This is to prevent further irritation or complications. Growth suppression has been observed in children using intranasal corticosteroids such as Flonase. It is recommended to regularly monitor growth in pediatric patients. |
What’s the Best Alternative to Nasacort and Flonase?
An alternative to Nasacort and Flonase may be considered for reasons like side effect concerns or a desire for more targeted relief.
While Nasacort and Flonase are both effective corticosteroid nasal sprays, some individuals may prefer products that combine multiple active ingredients for broader symptom relief. One such alternative is Allermi — it’s a nasal spray that contains a combination of triamcinolone (anti-inflammatory), oxymetazoline (decongestant), azelastine (antihistamine), and ipratropium (anticholinergic).
Allermi can be a great choice for those looking for an option that addresses multiple aspects of allergic rhinitis in one product. Users may feel quick improvement in nasal symptoms, possibly within 10 to 15 minutes.
Related: What to Do When Allergy Medicine Doesn't Work?
The Bottom Line
When managing allergy symptoms, Nasacort and Flonase are both effective, but the right choice depends on individual preferences, side effects, and how well the medications work. If you’re looking for a more targeted option that uses multiple ingredients, Allermi, with its combination of ingredients, could be better for you.
It’s important to speak with a healthcare provider before beginning or changing allergy medications to make sure you receive the right treatment.
References:
- Gawchik, S. M., & Saccar, C. L. (2000). A risk-benefit assessment of intranasal triamcinolone acetonide in allergic rhinitis. Drug safety, 23(4), 309–322. https://doi.org/10.2165/00002018-200023040-00004
- Holm, A., Dijkstra, M., Kleinjan, A., Severijnen, L. A., Boks, S., Mulder, P., & Fokkens, W. (2001). Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: effects of single allergen challenge. The Journal of allergy and clinical immunology, 107(4), 627–633. https://doi.org/10.1067/mai.2001.113520
