- Xyzal and Zyrtec are both second-generation antihistamines that provide 24-hour allergy relief. Both medications may cause drowsiness, but they are generally well-tolerated.
- Xyzal contains levocetirizine, while Zyrtec contains cetirizine, with cetirizine being slightly more effective over time according to some research.
- Allermi nasal spray works faster (within 10 minutes) and offers a multi-ingredient formula for comprehensive allergy relief. It also provides the benefit of personalized treatment.
Sneezing, an itchy nose, and other allergic rhinitis symptoms can make your day miserable, which leaves you looking for relief. Two common antihistamines you might come across are Xyzal and Zyrtec. Both promise to ease your symptoms, but how do they compare? Which one is better for your needs?
This article breaks down the differences between Xyzal and Zyrtec, including how they work and their side effects. If you need something that targets all your nasal symptoms with fewer side effects, we’ll also explore the best alternative.
Related: How Long Does It Take for Allergy Medicine to Work?
What is Xyzal?
Xyzal is a second-generation antihistamine available over the counter that provides 24-hour relief from allergy symptoms like sneezing, runny nose, itchy or watery eyes, and hives. Its active ingredient, levocetirizine, blocks histamine to prevent allergic reactions caused by both indoor and outdoor allergens [*].
Patients need to take Xyzal only once a day to stay symptom-free so that they can remain productive throughout the day. It comes in tablet and liquid forms, which makes it a convenient option for adults and children aged two and older.
What is Zyrtec?
Zyrtec is a widely used over-the-counter, second-generation antihistamine that treats a variety of allergy symptoms, including sneezing, runny nose, itchy or watery eyes, and itching caused by allergic rhinitis, dermatitis, and hives (urticaria).
Its active ingredient, cetirizine, works by blocking histamine, the chemical responsible for triggering allergic reactions. What sets cetirizine apart from levocetirizine, the active ingredient in Xyzal, is that cetirizine contains both active and inactive forms of the molecule, while levocetirizine includes only the active form.
Research shows that both cetirizine and levocetirizine effectively reduce allergy symptoms, but cetirizine appeared to work better than levocetirizine after 8 and 12 weeks of use [*].
Zyrtec offers 24-hour relief from seasonal allergies and year-round allergies. Available in tablets, liquid gels, chewables, and liquid, it provides flexible options for both adults and children to suit different needs and preferences.
Related: Zyrtec vs. Benadryl: Differences and Alternatives
Xyzal vs. Zyrtec
While both Xyzal and Zyrtec are effective at relieving allergy symptoms, there are key differences between the two. This comparison will help you determine which antihistamine is the right choice for you.
| Xyzal | Zyrtec | |
| Drug Class | Antihistamine | Antihistamine |
| Generic Name | Levocetirizine | Cetirizine |
| Indications | Treats allergic rhinitis (sneezing, runny nose, itchy/watery eyes) and chronic urticaria (hives) | Relieves hay fever, seasonal and perennial allergies, and chronic idiopathic urticaria (hives) |
| Side Effects | Common side effects include drowsiness, dry mouth, headache, and fatigue, while rare side effects may involve dizziness, sore throat, stomach pain, nausea, and allergic reactions. | Common side effects include drowsiness, dry mouth, headache, dizziness, and nausea, while rare side effects may include abdominal pain, diarrhea, and increased appetite. |
| Duration/Course | Provides 24-hour relief | Provides 24-hour relief |
| Onset | Within 1 hour | Within 1 hour |
| Drug Interaction | Significant interactions with MAOIs, moderate with other medications (bosutinib, ritonavir), and alcohol. Talk to your doctor about all the medications you're taking to avoid potential interactions. | May interact with NSAIDs (ibuprofen, diclofenac), alcohol, and certain medications. Talk to your doctor about all the medications you're taking to avoid potential interactions. |
| Warnings/Precautions | If you have kidney disease, a history of allergic reactions to antihistamines, or are breastfeeding, consult your doctor before using this medication. Avoid alcohol while using it, and if you are pregnant, speak with your doctor first. | Avoid if allergic to antihistamines. Caution with liver/kidney disease. Consult doctor if pregnant or breastfeeding. |
What’s the Best Alternative for Xyzal and Zyrtec?
While Xyzal and Zyrtec are popular choices for allergy relief, some people may prefer alternatives due to factors like side effects, personal preferences, or the need for faster relief.
For those looking for a more immediate solution, Allermi nasal spray may be the best option.
Unlike Xyzal and Zyrtec, which typically take around an hour to start working, Allermi nasal spray provides relief in just 10 minutes. Despite its rapid onset, it still offers 24-hour relief for relief all day long.
What sets Allermi nasal spray apart is its combination of multiple active ingredients, including an antihistamine, decongestant, anticholinergic, and anti-inflammatory components. This unique blend targets various aspects of nasal allergies. It’s also suitable for long-term use, so it’s a great option for those with persistent or chronic allergy symptoms. Also, since Allermi is a nasal spray and not a pill that you take by mouth, the medicine mainly goes to the nose and so generally has fewer side effects.
Best of all, with Allermi, you gain access to an allergist who can help tailor your treatment. Your Allermi formula can be adapted to meet your changing symptoms.
Related: What to Do When Allergy Medicine Doesn't Work?
The Bottom Line
Both Xyzal and Zyrtec are effective oral antihistamines that provide 24-hour relief from common allergy symptoms. Although these medications are convenient and widely available, some individuals may need quicker relief or prefer alternatives with additional active ingredients to target multiple allergy symptoms.
In such cases, Allermi nasal spray can be a better option. Taking a proactive approach to managing your allergies is key to finding the relief that works best for you.
References:
- Nettis, E., Calogiuri, G. F., Leo, E. D., Cardinale, F., Macchia, L., Ferrannini, A., & Vacca, A. (2008). Once daily levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria. Journal of Asthma and Allergy, 2, 17. https://doi.org/10.2147/jaa.s3022
- Lee, C. F., Sun, H. L., Lu, K. H., Ku, M. S., & Lue, K. H. (2009). The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 20(5), 493–499. https://doi.org/10.1111/j.1399-3038.2008.00816.x
