Scientific Index

OverviewThis Phase 2, double-blind, placebo-controlled clinical trial assessed the short-term efficacy and safety of combining mometasone furoate nasal spray (MFNS) with oxymetazoline (OXY) for the treatment of seasonal allergic rhinitis...

OverviewThis placebo-controlled trial assessed whether combining mometasone furoate (MFNS) and oxymetazoline (OXY) improves quality of life (QoL) in patients with seasonal allergic rhinitis (SAR). Subjects were randomized to one of...

OverviewThis randomized, double-blind, placebo-controlled, crossover study investigated whether intranasal fluticasone propionate can reverse oxymetazoline-induced tachyphylaxis (diminished decongestant response) and rebound congestion. Nineteen healthy volunteers were treated with oxymetazoline three times...

OverviewThis 60-week, randomized, double-blind clinical trial evaluated whether adding oxymetazoline (a topical decongestant) to intranasal corticosteroids (INS) could provide greater symptom relief in patients with chronic rhinitis compared to INS...

OverviewThis randomized controlled trial assessed the efficacy of combining oxymetazoline, a topical decongestant, with fluticasone furoate, an intranasal corticosteroid, in treating allergic rhinitis. Participants were assigned to receive either the...

Overview:This randomized, placebo-controlled clinical trial assessed whether adding oxymetazoline to intranasal corticosteroid therapy (mometasone furoate nasal spray, or MFNS) would enhance treatment outcomes in patients with nasal polyposis. The study...

Overview:This systematic review analyzed published studies on the combined use of intranasal corticosteroids (INCS) and oxymetazoline for treating chronic rhinitis—including both allergic and nonallergic types. The goal was to evaluate...

Overview:This prospective, open-label, single-arm, multicenter, real-world observational study evaluated the safety and effectiveness of a once-daily, fixed-dose nasal spray containing fluticasone furoate (a corticosteroid) and oxymetazoline hydrochloride (a decongestant) in...