Overview:
This prospective, open-label, single-arm, multicenter, real-world observational study evaluated the safety and effectiveness of a once-daily, fixed-dose nasal spray containing fluticasone furoate (a corticosteroid) and oxymetazoline hydrochloride (a decongestant) in patients diagnosed with allergic rhinitis (AR). A total of 388 patients were enrolled and treated for 28 days.
The Takeaways:
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Treatment with the fluticasone–oxymetazoline (FF + OXY) spray led to significant reductions across all measured symptom scores:
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Total Nasal Symptom Score (TNSS): decreased from 7.18 ± 3.38 to 0.20 ± 0.84
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Total Ocular Symptom Score (TOSS): decreased from 2.34 ± 2.29 to 0.09 ± 0.53
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Total Symptom Score (TSS): decreased from 9.51 ± 4.94 to 0.29 ± 1.32
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All reductions were statistically significant (p < 0.001).
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The treatment was well tolerated, with no serious adverse events reported.
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No signs of rebound congestion were observed, despite the 28-day use of oxymetazoline.
Why It Matters:
Oxymetazoline is a powerful decongestant, but its use has traditionally been restricted due to concerns over rebound congestion with prolonged use. This study confirms that when combined with a corticosteroid in a fixed-dose format, oxymetazoline can be safely extended long-term—offering rapid, sustained, and safe relief from allergic rhinitis symptoms in a real-world setting.
The Link to Allermi:
Allermi’s formulation strategy mirrors this evidence by combining low-dose oxymetazoline with corticosteroids to deliver fast and lasting congestion relief, without the historical safety concerns. This real-world study validates Allermi’s personalized, science-backed nasal spray approach—confirming that carefully dosed oxymetazoline, even when used longer than traditional limits, can be safe and effective when paired with a steroid.
For more details, refer to the full study: A Real-World Observational Study to Evaluate the Safety and Effectiveness of Fluticasone Furoate–Oxymetazoline Fixed Dose Combination Nasal Spray in Patients with Allergic Rhinitis
