Scientific Index

Overview:This randomized, double-blind, placebo-controlled study assessed whether extended use of oxymetazoline nasal spray—typically cautioned against due to risks of rebound congestion and tachyphylaxis—would actually produce such effects in healthy individuals....

OverviewThis randomized, double-blind, placebo-controlled study investigated how different doses of intranasal oxymetazoline impact nasal airflow and congestion symptoms in healthy adults without nasal obstruction. Researchers assessed nasal airway resistance (NAR),...

OverviewThis study examined the impact of a topical decongestant on nasal mucosal blood flow in both healthy individuals and those with early-stage acute rhinitis. Using the 133Xe wash-out method, researchers...

Overview:This 2-week, multicenter, randomized, double-blind clinical trial assessed the efficacy of combining intranasal azelastine (antihistamine) with fluticasone propionate (corticosteroid) for patients with moderate to severe seasonal allergic rhinitis (SAR) during...

Overview:This 12-month, multicenter, open-label study evaluated the long-term safety and efficacy of triamcinolone acetonide (TAA) aqueous nasal spray for treating perennial allergic rhinitis (PAR). The study followed patients who had...

Overview:This multicenter, prospective, randomized, open-label study assessed the long-term safety of intranasal triamcinolone acetonide (TAA) aqueous spray in patients with perennial allergic rhinitis (PAR). The primary focus was on nasal...

Overview:This one-year, open-label extension of a prior 12-week, double-blind clinical trial assessed the long-term safety and efficacy of once-daily triamcinolone acetonide nasal aerosol in 93 patients with perennial allergic rhinitis...

Overview:This comprehensive review explores the mechanisms, pharmacokinetics, and safety profiles of intranasal corticosteroids (INSs), which are widely used to treat allergic rhinitis, rhinosinusitis, and nasal polyposis. The paper highlights the...