Scientific Index

Overview:This multicenter, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of triamcinolone acetonide (TAA) aqueous nasal spray in 178 patients with perennial allergic rhinitis (PAR). Participants were treated once...

Overview:This randomized, placebo-controlled clinical trial assessed whether adding oxymetazoline to intranasal corticosteroid therapy (mometasone furoate nasal spray, or MFNS) would enhance treatment outcomes in patients with nasal polyposis. The study...

Overview:This systematic review analyzed published studies on the combined use of intranasal corticosteroids (INCS) and oxymetazoline for treating chronic rhinitis—including both allergic and nonallergic types. The goal was to evaluate...

Overview:This prospective, open-label, single-arm, multicenter, real-world observational study evaluated the safety and effectiveness of a once-daily, fixed-dose nasal spray containing fluticasone furoate (a corticosteroid) and oxymetazoline hydrochloride (a decongestant) in...

Overview:This pilot study evaluated the safety and efficacy of combining oxymetazoline hydrochloride (OXY) with mometasone furoate (MNS) nasal spray in adults with a ≥1-year history of moderate-to-severe nasal congestion that...

Overview:This randomized, double-blind, active-controlled, multicenter study evaluated a fixed-dose combination (FDC) of fluticasone furoate (27.5 mcg) and oxymetazoline hydrochloride (50 mcg) nasal spray, administered once nightly, in patients with moderate-to-severe...

Overview:This meta-analysis evaluated the efficacy of nasal saline irrigation (NSI) in managing allergic rhinitis (AR) across children and adults. The analysis included randomized controlled trials comparing NSI to no treatment...

Overview:This review article summarizes the mechanism, clinical efficacy, and safety of azelastine hydrochloride nasal spray in the treatment of seasonal and perennial allergic rhinitis. Azelastine, a second-generation intranasal antihistamine, works...